http://medulloblastoma-cancer.com Just another WordPress weblog Mon, 21 Apr 2008 17:52:34 +0000 http://backend.userland.com/rss092 en Medulloblastoma arises in the cerebellum and is the most common malignant brain tumour of childhood, however its molecular basis is not well understood. To assess the role of aberrant epigenetic events in medulloblastoma and identify critical genes in its development, we profiled the promoter methylation status of 11 candidate tumour-suppressor ... http://medulloblastoma-cancer.com/2008/04/21/medulloblastoma-cancer-6/ Oncology Research,1 Discovery Technologies, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 021392 Received 29 November 2006/ Returned for modification 1 February 2007/ Accepted 11 April 2007 Bmi-1 and Mel-18 are structural homologues that belong to the Polycomb group of transcriptional regulators and are believed to stably maintain repression of gene ... http://medulloblastoma-cancer.com/2008/04/21/contribution-of-polycomb-homologues-bmi-1-and-mel-18-to-medulloblastoma-pathogenesis/ P53 mutations are relatively uncommon in medulloblastoma, but abnormalities in this cell cycle pathway have been associated with anaplasia and worse clinical outcomes. We correlated p53 protein expression with pathological subtype and clinical outcome in 75 embryonal brain tumors. The presence of JC virus, which results in p53 protein accumulation, ... http://medulloblastoma-cancer.com/2008/04/21/background/ A team of investigators led by St. Jude Children's Research Hospital has announced that improvements in the treatment of the childhood brain cancer medulloblastoma have significantly increased the rate of survival of children with this disease. The treatment increased the overall five-year survival for 86 children with average-risk medulloblastoma from ... http://medulloblastoma-cancer.com/2008/04/21/medulloblastoma-treatment/ The author has no significant financial interest or other relationship with the manufacturers of any products or providers of any service mentioned in this article. JAMES M. OLSON, MD, PhD Sri Gururangan and Henry Friedman present a thoughtful review of advances in pediatric neurooncology. Coupled with the recent review of pediatric brain ... http://medulloblastoma-cancer.com/2008/04/21/recent-advances-in-the-treatment-of-pediatric-brain-tumors/ In very young children with surgically treated medulloblastoma with metastases, lengthy remissions can be obtained with intensive chemotherapy without radiation therapy, according to a report in the March 10th issue of The New England Journal of Medicine. Investigators also found that cognitive function during follow-up is not affected as drastically ... http://medulloblastoma-cancer.com/2008/04/21/abstract/ David M. Berman,125* Sunil S. Karhadkar,125* Andrew R. Hallahan,67 Joel I. Pritchard,7 Charles G. Eberhart,2 D. Neil Watkins,4 James K. Chen,15 Michael K. Cooper,135 Jussi Taipale,15 James M. Olson,67 Philip A. Beachy15 Constitutive Hedgehog (Hh) pathway activity is associated with initiation of neoplasia, but its role in the continued growth ... http://medulloblastoma-cancer.com/2008/04/21/medulloblastoma-growth-inhibition-by-hedgehog-pathway-blockade/ Department of Radiation Oncology, Cancer Hospital (Institute), Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China and 2 Department of Radiation Oncology, St Jude Children's Research Hospital, Memphis, TN, USA For reprints and all correspondence: Yueping Liu, Department of Radiation Oncology, Cancer Hospital (Institute), Chinese Academy of ... http://medulloblastoma-cancer.com/2008/04/21/radiation-treatment-for-medulloblastoma-a-review-of-64-cases-at-a-single-institute/ Aaron was born on the afternoon of 9th January at Waitakere Hospital in West Auckland.  Aaron was our second born (proud parents being Sue and Murray) and we already had a bubbly 2 year old daughter Karina who was thrilled to have a new brother.  Murray and myself were just ... http://medulloblastoma-cancer.com/2008/04/21/medulloblastoma-cancer-5/ Medulloblastoma is a primitive neuronal tumour, usually arising in childhood. It is characterized by its propensity for spread via the cerebrospinal fluid (CSF). Treatment is by surgical resection followed by craniospinal radiotherapy (CSRT) and adjuvant chemotherapy. CSRT is one of the most complex radiotherapy (RT) techniques planned in most oncology ... http://medulloblastoma-cancer.com/2008/04/21/paediatric-medulloblastoma-associated-with-poor-prognosis-and-short-volume-doubling-time/